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Hepatic biotransformation of MLN8054 was researched in vitro applying human liver S9 fractions (Data on file, Millennium). Glucuronidation on the carboxylate moiety of MLN8054 to an acyl glucuronide was the predominant system of biotransformation, Hydroxylation on the azepine moiety of MLN8054 was the foremost phase 1 biotransformation pathway. Glu
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